Hepatocellular carcinoma-Fibrolamellar variant

Hepatocellular carcinoma-Fibrolamellar variant
Common variant in young adults 20-40 years.  Is  characterized by  oncocytic cells in dense acellular collagen bundles.
Not association  with hepatitis B virus or  cirrhosis  of liver.
Treatment is aggresive surgery.
Macroscopic is a lesion singl, large  hard, white-brown tumor.  Are present  fibrous bands  in liver parenchimat and central stellate scar.
This tumor at is more common in left lobe of liver. Present  bile staining, hemorrhage and necrosis.
Microscopic diagnosis:
Are present  nests, sheets of  oncocytic cells in  collagen bundles. This bundle are  arranged in parallel lamellae way.
Cells are large and polygonal, abundant, eosinophilic cytoplasm.
Can be present  pale bodies : are PAS+ hyaline globules.
Vascular invasion and necrosis  in carcinoma fibrolamelar is frecvent
Radiologic calcification corresponds to necrosis  reaction.
For diagnosis i used imunochemistry like: HepPar and CK7 which help me in diagnosis.
Thanks
+liver
+fibrolamelar  hepatic carcinoma